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KMID : 0605720080140010142
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Journal of the Korean Society of Biological Therapies in Psychiatry
2008 Volume.14 No. 1 p.142 ~ p.144
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Venlafaxine-Induced Mania After Nortriptyline-Induced Hypomania in Unipolar Depression
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Chae Beang-Jin
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Abstract
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Venlafaxine is an effective antidepressant medication which acts through the blockage of serotonergic or noradrenergic receptors. I present a case of venlafaxine induced mania in a unipolar depressed 33 year old woman. She had a history of nortriptyline induced hypomania and a family history of suicide. 51 days after beginning venlafaxine, she began developing manic switch. Twenty five days after stopping venlafaxine, manic symptoms disappeared. This case suggests that venlafaxine may be associated with a switch to mania or hypomania in unipolar depressive patient with bipolarity.
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KEYWORD
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Venlafaxine, Mania, Hypomania, Switch, Unipolar depression
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